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Project Number: | I01BX001137-05A2 |
| Title: | Reducing Nephrotoxicity while enabling read through of missense stop codons by Gentamicin congeners |
| Principal Investigator: | Robert L. Bacallao |
| Location: | Indianapolis, IN |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2021 |
| FY 2021 Funding Amount: | $82,500 |
| Total Award Amount (all years): |
$787,296 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Aminoglycoside antibiotics remain first line therapy for gram negative infections and are used in conjunction with other antibiotics for certain gram positive organisms. Aminoglycosides, especially gentamicin, have also been used to suppress premature stop codon termination of protein synthesis leading to monogenic diseases like cystic fibrosis and Duchene's Muscular Dystrophy. Unfortunately, they still have an unacceptably high rate of dose and duration-dependent nephrotoxicity, especially in t... |