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Project Number: | I01BX002180-05 |
| Title: | Interaction of environment and genetics in predisposition to inflammatory arthritis |
| Principal Investigator: | Holly Rosenzweig |
| Location: | Portland, OR |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $302,453 |
| Total Award Amount (all years): |
$1,397,436 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Arthritis, a chronic immune-mediated disease involving painful destruction of the joints, presents a considerable medical challenge to our US Veteran population due to incomplete understanding of its pathogenesis. An emerging paradigm proposes that self-reactive (or autoreactive) T cells influenced by genetic-environmental interactions initiate and perpetuate disease. Understanding how these factors contribute to generation of autoreactive T cells and their subsequent expansion and ability to ca... |