5HT modulation of arousal and chemoreflex responses in intact and SCI mice.
Jason H. Mateika
Allen Park, MI
Congressional District Code:
Biomedical Laboratory R&D
January 2018 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Sleep apnea is associated with autonomic, cardiovascular, metabolic and cognitive co‐morbidities. The incidence of sleep apnea in the United States ranges from 2‐4 % in the general population, and is up to 15 times greater in individuals with spinal cord injury (SCI). Adjustments in the neural modulation of the arousal threshold (AT), chemoreflex sensitivity to hypoxia and hypercapnia (CS) and upper airway patency are three critical factors that contribute to exacerbation of sleep apnea. Th...