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Funded Project Details - FY2021

Project Number:

Title: 5HT modulation of arousal and chemoreflex responses in intact and SCI mice.
Principal Investigator:

Jason H. Mateika

Location: Allen Park, MI
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2022
FY 2021 Funding Amount: $87,154
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Sleep apnea is associated with autonomic, cardiovascular, metabolic and cognitive co‐morbidities.  The  incidence of sleep apnea in the United States ranges from 2‐4 % in the general population, and is up to 15 times  greater in individuals with spinal cord injury (SCI). Adjustments in the neural modulation of the arousal  threshold (AT), chemoreflex sensitivity to hypoxia and hypercapnia (CS) and upper airway patency are three  critical factors that contribute to exacerbation of sleep apnea. Th...

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