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Project Number: | I01BX000446-08A1 |
| Title: | Dynamic Regulation of Erythropoietin Gene Expression in Mammals |
| Principal Investigator: | Joseph A Garcia |
| Location: | Bronx, NY |
| Congressional District Code: | 30 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2017 - December 2021 |
| FY 2021 Funding Amount: | $123,750 |
| Total Award Amount (all years): |
$765,575 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Anemia, a common condition in Veteran patients, is a potent risk factor for increased morbidity and mortality when accompanying other disease states. Current therapies for anemia involve non-physiological bolus administration of erythropoietin (Epo), an endocrine factor produced in the adult kidney and liver with severe anemia. Bolus Epo administration has untoward effects, including an increased thrombotic risk and a stimulatory effect on cancer. Understanding how Epo is regulated will allow in... |