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Project Number: | I01BX003304-01A2 |
| Title: | Caveolins, Striatal Toxicity and Methamphetamine Addiction |
| Principal Investigator: | Chitra Mandyam |
| Location: | San Diego, CA |
| Congressional District Code: | 52 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | June 2017 - September 2021 |
| FY 2021 Funding Amount: | $274,521 |
| Total Award Amount (all years): |
$1,421,535 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Summary Dopamine D1 receptors (D1Rs) in the dorsal striatum are hypothesized to play a major role in methamphetamine (Meth) addiction, and self-administration paradigms of Meth intake (clinically relevant models of Meth addiction) have reported that Meth self-administration increases D1R expression in the striatum and systemic D1R blockade decreases responding to Meth and reduces Meth seeking. Systemic D1 receptor antagonism in Meth experienced animals also prevented some aspects of maladaptive... |