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Project Number: | IK2RX002488-01 |
| Title: | Molecular characterization of a rat model of chronic mild traumatic brain injury |
| Principal Investigator: | Todd E White |
| Location: | Decatur, GA |
| Congressional District Code: | 5 |
| Research Service: | Rehabilitation R&D |
| Project Period: | April 2017 - March 2022 |
| FY 2021 Funding Amount: | $251,293 |
| Total Award Amount (all years): |
$1,238,665 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The proposed research will use a personalized precision medicine approach to establish a preclinical model of chronic repetitive mild traumatic brain injury (rmTBI). The first objective of the proposed research is the elucidation of the blood molecular signature for chronic rat rmTBI. The second objective is to test whether administration of the neuroprotective agent neuregulin-1 (NRG-1) improves behavioral performance in this model. This is highly relevant because a significant military and vet... |