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Project Number: | I01RX002099-01A1 |
| Title: | Modulating microglial phenotype to prevent SCI-induced central neuropathic pain |
| Principal Investigator: | Mousumi Ghosh |
| Location: | Miami, FL |
| Congressional District Code: | 18 |
| Research Service: | Rehabilitation R&D |
| Project Period: | June 2017 - December 2022 |
| FY 2021 Funding Amount: | $181,732 |
| Total Award Amount (all years): |
$1,083,102 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: A significant percentage (40-50%) of individuals with spinal cord injury (SCI) exhibit central neuropathic pain (CNP), a condition of persistent discomfort involving often unbearable burning, pricking, shooting and/or evoked types of pain in response to light touch. CNP appears more frequently in females, who also exhibit a greater sensitivity to pain than males. CNP develops in response to a dysregulation of somatosensory signaling and is largely refractory to conventional therapeutic intervent... |