Tissue Engineered Total Disc Replacement in a Large Animal Model
Congressional District Code:
April 2017 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Title: Tissue Engineered Total Disc Replacement in a Large Animal Model The objective of this project is to develop a tissue-engineered construct including an engineered nucleus pulposus and annulus fibrosus to treat degenerative changes of the intervertebral disc (IVD). In Specific Aim 1, we will build on our preliminary small animal studies to construct cell- seeded DAPS whose geometric dimensions are comparable to human and goat IVDs. A novel compression-torsion bioreactor and simulated ex vi...