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Funded Project Details - FY2021




Project Number:

I01RX002274-01A1
Title: Tissue Engineered Total Disc Replacement in a Large Animal Model
Principal Investigator:

Harvey Smith

Location: Philadelphia, PA
Congressional District Code: 2
Research Service: Rehabilitation R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $137,489
Total Award Amount
(all years):
$1,099,920
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Title: Tissue Engineered Total Disc Replacement in a Large Animal Model The objective of this project is to develop a tissue-engineered construct including an engineered nucleus pulposus and annulus fibrosus to treat degenerative changes of the intervertebral disc (IVD). In Specific Aim 1, we will build on our preliminary small animal studies to construct cell- seeded DAPS whose geometric dimensions are comparable to human and goat IVDs. A novel compression-torsion bioreactor and simulated ex vi...



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