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Funded Project Details - FY2021

Project Number:

Title: Pathogenic role of thrombospondin-1 in acute and chronic liver failure
Principal Investigator:

Matthew McMillin

Location: Temple, TX
Congressional District Code: 31
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - September 2022
FY 2021 Funding Amount: $216,547
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Liver failure is characterized by a loss of hepatocytes or hepatic function due to an acute liver insult or chronic liver disease. Liver failure is often accompanied by neurological complications, called hepatic encephalopathy, which lead to reduced quality of life and increased mortality in patients. Acute liver failure is characterized by hepatocyte necrosis that occurs at a rate that is too rapid for the liver to regenerate resulting in a loss of liver function. In contrast, chronic liver dis...

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