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Project Number: | I01BX003401-01A1 |
| Title: | Mechanisms of Neuroprotective Therapy in TBI |
| Principal Investigator: | Avtar K. Singh |
| Location: | Charleston, SC |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - December 2020 |
| FY 2021 Funding Amount: | $41,250 |
| Total Award Amount (all years): |
$683,383 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Traumatic brain injury (TBI) is a neurodegenerative disease in which nitric oxide (NO)-based anti-inflammatory and anti-excitotoxicity mechanisms are derailed, resulting in a disturbed NO metabolome. NO metabolites S- nitrosoglutathione (GSNO) and peroxynitrite (ONOO-) participate in opposing mechanisms (neuroprotection and neurodegeneration, respectively) by regulation of neuronal nitric oxide synthase (nNOS)- and calpain- mediated deleterious mechanisms. A prolonged and sustained increase in n... |