Functional role of STRAP in colorectal cancer metastasis and in chemoresistance
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Biomedical Laboratory R&D
January 2017 -
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Project Summary/Abstract Despite the high rate of recurrence following therapy in colorectal cancer (CRC) and relatively rapid pace of cancer stem-like cell research in solid tumors, researches are impeded due to limited knowledge of the CRC epithelial stem cell hierarchy and complex heterogeneity of the disease. Recent evidences suggest that colorectal tumors comprise a small fraction of cancer stem-like cells that seed the tumor bulk and may be responsible for metastasis, resistance to therap...