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Project Number: | I01BX003279-01A2 |
| Title: | Dopamine D2 Receptor Splice Variants and Autoreceptor Function |
| Principal Investigator: | Kim Arthur Neve |
| Location: | Portland, OR |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - March 2021 |
| FY 2021 Funding Amount: | $225,456 |
| Total Award Amount (all years): |
$1,777,221 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The five subtypes of dopamine receptors (D1-D5) are members of the superfamily of G protein-coupled receptors. The D1 and D2 subtypes are the most abundant and mediate most classic dopamine-dependent behaviors. This application is focused on the D2 receptor and, in particular, on the functional significance of a 29-residue fragment in the third cytoplasmic loop that is alternatively spliced to produce the short and long forms of the D2 receptor, D2S and D2L. Considerable evidence indicates that... |