Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX003256-01A2
Title: Neo-antigens and the function of HLA-DR alleles in autoimmune arthritis
Principal Investigator:

Edward F. Rosloniec

Location: Memphis, TN
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $253,282
Total Award Amount
(all years):
$1,463,482
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract The focus of this proposal is to identify the role of posttranslational modifications of proteins and peptides in the development of an autoimmune T cell response. The hypothesis directing these studies is that inflammation induces localized posttranslational modifications (PTM) of proteins, and that these modifications induce epitope spreading by generating neo-epitopes which become focal points of autoimmune T cell stimulation that perpetuate the autoimmune disease. Recent clinical o...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.