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Funded Project Details - FY2021




Project Number:

I01BX001556-05A2
Title: Impact of Corticotropin Releasing Factor on Sleep Regulation
Principal Investigator:

Ronald S. Szymusiak

Location: Sepulveda, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$713,597
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Insomnia and disturbed sleep are common symptoms in mood and anxiety disorders. Depression and PTSD are associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. Brain levels of corticotrophin-releasing factor (CRF), a critical neuropeptide regulator of the HPA axis, are chronically elevated in these disorders. CRF has well characterized wake-promoting/sleep-disruptive effects. Previous work from our laboratory and others has identified GABAergic neurons in the preoptic hypot...



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