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Project Number: | I01BX001556-05A2 |
| Title: | Impact of Corticotropin Releasing Factor on Sleep Regulation |
| Principal Investigator: | Ronald S. Szymusiak |
| Location: | Sepulveda, CA |
| Congressional District Code: | 33 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - March 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$713,597 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Insomnia and disturbed sleep are common symptoms in mood and anxiety disorders. Depression and PTSD are associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. Brain levels of corticotrophin-releasing factor (CRF), a critical neuropeptide regulator of the HPA axis, are chronically elevated in these disorders. CRF has well characterized wake-promoting/sleep-disruptive effects. Previous work from our laboratory and others has identified GABAergic neurons in the preoptic hypot... |