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Project Number: | I01BX000136-08 |
| Title: | Mechanism of GDNF regulation of Hepatic Steatosis |
| Principal Investigator: | Shanthi Srinivasan |
| Location: | Decatur, GA |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2021 |
| FY 2021 Funding Amount: | $82,500 |
| Total Award Amount (all years): |
$762,500 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in Veterans and its prevalence continues to increase, with the growing obesity epidemic. Hepatic steatosis is a component of NAFLD, wherein there is accumulation of triglycerides in the liver. Recently we published that GDNF transgenic mice fed a high fat diet are protected from obesity and the development of hepatic steatosis despite similar food intake and physical activity. GDNF transgenic mice over express G... |