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Project Number: | I01BX001974-05 |
| Title: | The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1 |
| Principal Investigator: | Robert A. Bonomo |
| Location: | Cleveland, OH |
| Congressional District Code: | 11 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - December 2020 |
| FY 2021 Funding Amount: | $41,250 |
| Total Award Amount (all years): |
$716,782 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: After more than 30 years of using β-lactamase inhibitors (BLIs) in the treatment of patients, pressing questions still remain at the forefront of our clinical efforts. Although, the value of β-lactam/BLI combinations (e.g., piperacillin/tazobactam) was well-established by the 1990s, the rapid emergence of β-lactamases that hydrolyzed expanded spectrum cephalosporins, carbapenems and were resistant to inactivation by BLIs created a global crisis in antimicrobial chemotherapy and propelled the que... |