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Funded Project Details - FY2021

Project Number:

Title: The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1
Principal Investigator:

Robert A. Bonomo

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $41,250
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


After more than 30 years of using β-lactamase inhibitors (BLIs) in the treatment of patients, pressing questions still remain at the forefront of our clinical efforts. Although, the value of β-lactam/BLI combinations (e.g., piperacillin/tazobactam) was well-established by the 1990s, the rapid emergence of β-lactamases that hydrolyzed expanded spectrum cephalosporins, carbapenems and were resistant to inactivation by BLIs created a global crisis in antimicrobial chemotherapy and propelled the que...

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