Office of Research & Development |
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Project Number: | I01BX003664-01 |
Title: | Pathophysiology of Extracellular Matrix and Desmin Breakdown in Volume Overload Heart |
Principal Investigator: | Louis J. Dellitalia |
Location: | Birmingham, AL |
Congressional District Code: | 7 |
Research Service: | Biomedical Laboratory R&D |
Project Period: | January 2017 - August 2021 |
FY 2021 Funding Amount: | $71,250 |
Total Award Amount (all years): |
$762,436 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The importance of the extracellular matrix loss in adverse LV remodeling is well established in the isolated pure volume overload of mitral regurgitation. Here the Principal Investigator reports a newly described breakdown of cardiomyocyte cytoskeletal protein desmin that adds an important intracellular structural defect with a direct impact on cardiomyocyte contractile function. This extracellular and intracellular protein breakdown mandates a novel medical therapy that enhances fibroblast extr... |