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Project Number: | I01BX003377-01 |
| Title: | Interleukin-4 as a Novel therapy for Traumatic Brain Injury |
| Principal Investigator: | Jun Chen |
| Location: | Pittsburgh, PA |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - September 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$754,994 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): White matter (WM) injury, characterized by demyelination and loss of axonal integrity, is an important cause of long-term sensorimotor and cognitive deficits after traumatic brain injury (TBI). A persistent pro-inflammatory microenvironment after TBI is considered one underlying mechanism that hinders oligodendrocyte precursor cell (OPCs) differentiation and maturation into myelinating oligodendrocytes (OLs). Accumulating evidence suggests that th... |