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Project Number: | I01BX002964-01A2 |
| Title: | Regulation of Functional Activity of Osteoclasts |
| Principal Investigator: | K. H. William Lau |
| Location: | Loma Linda, CA |
| Congressional District Code: | 31 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2016 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$751,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Past work of this group has demonstrated that an osteoclastic protein-tyrosine phosphatase (PTP-oc) is a positive activator of the osteoclast activity. Recent preliminary studies have disclosed four exciting discoveries relevant to the mechanism of how PTP-oc expression in osteoclasts is regulated: First, PTP-oc expression is controlled primarily by post-transcriptional mechanisms. Second, the post-transcriptional regulation of PTP-oc expression in o... |