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Project Number: | I01BX000963-05A2 |
| Title: | Mechanisms of Virus-induced Injury in the Brain and Spinal Cord |
| Principal Investigator: | Kenneth L. Tyler |
| Location: | Denver, CO |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2017 - December 2021 |
| FY 2021 Funding Amount: | $37,500 |
| Total Award Amount (all years): |
$668,315 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Treatments for virus-induced diseases of the central nervous system (CNS) are sub-optimal or non- existent. Virus infection of the CNS results in a robust host neuroinflammatory response, defined by the activation of resident CNS immune cells (microglia and astrocytes) and the up-regulation of pro-inflammatory genes. The role of these responses in virus-induced CNS disease remains unclear. Neuroinflammatory responses likely play a protective role... |