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Project Number: | I01BX003385-01 |
| Title: | Therapeutic Development in Segmental Demyelination |
| Principal Investigator: | Jun Li |
| Location: | Allen Park, MI |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2016 - September 2021 |
| FY 2021 Funding Amount: | $30,000 |
| Total Award Amount (all years): |
$652,500 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Demyelination shunts depolarizing current out of the nerve. As a result, nerve conduction of action potentials can be slowed or even eliminated. The later is known as conduction block. This change causes neurological disabilities such as sensory loss, vision loss, and limb paralysis in a variety of neurological diseases. We have found that patients and mice with FIG4 deficiency develop a demyelinating neuropathy. This demyelination closely recapi... |