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Project Number: | I01BX002539-01A2 |
| Title: | Differential cardioprotection by mitochondrial Ca2+ sensitive potassium channels |
| Principal Investigator: | David F. Stowe |
| Location: | Milwaukee, WI |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2016 - March 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$676,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): We recently identified and characterized small KCa (mSKCa) channels in the inner mitochondrial membrane (IMM) of guinea pig and human cardiac myocytes. A related class channel is the big mBKCa channel found in cardiac myocytes and other cell types. Reactive O2 species (ROS) are believed to be responsible for mediating protective effects of mKCa channel openers, but it is not known how mKCa channel opening acts to stimulate mild ROS generation or h... |