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Funded Project Details - FY2021




Project Number:

I01BX003015-01A2
Title: Lipid Rafts: Mechanosensors of the distal nephron
Principal Investigator:

Rajeev Rohatgi

Location: Northport, NY
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$753,838
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

 DESCRIPTION (provided by applicant): Mechanical forces and, in particular, fluid shear stress (FSS), play critical roles in endothelia t regulate vascular reactivity and in renal epithelia to affect transepithelial cation transport that collectively, determine blood pressue (BP). Mechano-regulation of tubular cation transport is an important regulator of renal sodium (Na) homeostasis and infers the existence of mechano-sensors in renal epithelia. Cholesterol (chol)-rich lipid rafts (...



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