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Project Number: | I01RX001964-01A1 |
| Title: | Reducing Brain Hyperglycolysis: A Novel Strategy for Hyperglycemia after Stroke |
| Principal Investigator: | Yuchuan Ding |
| Location: | Allen Park, MI |
| Congressional District Code: | 13 |
| Research Service: | Rehabilitation R&D |
| Project Period: | March 2016 - February 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$1,077,472 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION: Hyperglycemia (i.e., elevated blood glucose) affects approximately 40% of acute ischemic stroke patients, regardless of a diabetes history. In experimental and clinical studies, hyperglycemia exacerbates ischemic brain injury by perpetuating aberrant glucose metabolism and hyperglycolysis-associated oxidative injury from excessive production of reactive oxygen species (ROS). Clinically, to address hyperglycemia in stroke, insulin has been implemented to normalize serum gluco... |