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Funded Project Details - FY2021

Project Number:

Title: Multifunctional rehabilitative therapy to reduce Alzheimer pathology after TBI
Principal Investigator:

Milos Ikonomovic

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Rehabilitation R&D
Project Period: April 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION : Traumatic brain injury (TBI) is a prevalent cause of disability in Veterans and a major environmental risk factor for developing Alzheimer's disease (AD) dementia. A key neuropathological link between the two conditions, increased brain concentration of amyloid-β (Aβ), is also a therapeutic target. Environmental enrichment (EE) is a non-invasive therapeutic paradigm that can reduce pathological concentrations of Aβ in the brain. Our pilot data in uninjured genetically modif...

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