Office of Research & Development |
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Project Number: | I01RX001807-01A1 |
Title: | Maximizing Spike - Timing Dependent Plasticity after Spinal Cord Injury |
Principal Investigator: | Martin Oudega |
Location: | Hines, IL |
Congressional District Code: | 14 |
Research Service: | Rehabilitation R&D |
Project Period: | April 2016 - March 2021 |
FY 2021 Funding Amount: | $0 |
Total Award Amount (all years): |
$1,099,919 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Abstract: Our overall goal is to develop new clinical approaches to restore upper-limb function after incomplete cervical spinal cord injury (SCI). Corticospinal tract (CST) axons are involved in controlling upper-limb function. Paired-pulse induced spike-timing dependent plasticity (STDP) enhances synaptic strength between residual CST axons and spinal motoneurons (SMNs) resulting in temporary improvements in upper-limb function in humans with inco... |