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Project Number: | I01BX000737-05 |
| Title: | Macrophage-mediated gene delivery of neurotrophic factors for Parkinson's disease |
| Principal Investigator: | Senlin Li |
| Location: | San Antonio, TX |
| Congressional District Code: | 21 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2016 - December 2020 |
| FY 2021 Funding Amount: | $36,577 |
| Total Award Amount (all years): |
$1,395,051 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The development of a neuroprotective/restorative therapy for Parkinson's disease (PD) would be a major therapeutic advance, particularly for our veterans. Glial cell line-derived neurotrophic factor (GDNF) has been the most potent trophic molecule to dopamine neurons affected in PD. GDNF requires focal delivery as it does not cross the blood-brain barrier (BBB). However, clinical trials of GDNF in PD patients have given mixed results. It is challenging to achieve therapeutic levels of GDNF for a... |