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Funded Project Details - FY2021




Project Number:

I01BX002129-01A2
Title: M3R, MMP1 and Colon Cancer Dissemination
Principal Investigator:

Jean-Pierre Raufman

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2015 - December 2020
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$783,750
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

DESCRIPTION (provided by applicant): Colon cancer is the third most common cancer in veterans; one-third of those with colon cancer are anticipated to die, largely from metastases. Current therapeutic options for advanced colon cancer are limited. The focus of our work is to elucidate the role of M3 muscarinic receptor (M3R) activation in colon cancer dissemination, and to use this knowledge to develop novel biomarkers and innovative therapies. M3R (encoded by CHRM3 ) are commonly ov...



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