Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX002307-01A1
Title: Sensitization of lung cancer to EGFR tyrosine kinase inhibitors
Principal Investigator:

Hannah Rabinowich

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: April 2015 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$1,099,064
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

DESCRIPTION (provided by applicant): The major limitation of lung cancer therapies that selectively target the Epidermal Growth Factor Receptor (EGFR) signaling network is the emergence of secondary drug resistance mechanisms. Currently, 40% of the cases of acquired resistance to EGFR Tyrosine Kinase Inhibitors (TKIs) are mechanistically unexplained. However, there are still no effective therapies for Non Small Cell Lung Cancer (NSCLC) harboring the secondary EGFR mutation, T790M, wh...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.